Xeroderma pigmentosum is a severe, genetically linked skin cancer in which dna repair mechanisms are impaired. why would sufferers of this condition need to stay out of the sun?

Answers

Answer 1
Final answer:

Individuals with Xeroderma pigmentosum must avoid sun exposure due to damaged DNA repair mechanisms leading to a significantly higher risk of skin cancer and severe skin damage from UV light.

Explanation:

Sufferers of Xeroderma pigmentosum (XP) need to stay out of the sun due to their impaired DNA repair mechanisms, particularly the nucleotide excision repair (NER) mechanism. This condition leads to an inability to repair thymine dimers and other bulky DNA adducts caused by exposure to UV light from the sun. These unrepaired thymine dimers distort the DNA structure, significantly increasing the risk of skin damage, skin lesions, and a high rate of sunlight-induced skin cancer.

The extreme photosensitivity displayed by individuals with XP, along with the potential for skin atrophy, hyperpigmentation, and even neurologic disorders, underscores the necessity for such individuals to limit sun exposure as much as possible.

Unfortunately, there is currently no effective treatment for XP, making sun avoidance and protection critical for managing this condition.


Related Questions

Hypertension is defined as a systolic/diastolic blood pressure at or above ____ mm hg

Answers

 It is 130/90 or 140/90 mmHg. for every 

Exceptionally large babies increase a mother's mortality risk when giving birth and exceptionally small babies tend to die at birth or shortly afterward. for these reasons, birth weight in human babies is generally:

Answers

The weight that is considered normal for a newly born baby that is born between 37 and 40 weeks is 2.7 to 4.1 kg or 6 to 9 lbs whereas exceptionally big babes weigh in average at 5.00 kg or 11 lbs.

When the blood glucose level rises after a meal, the first organ to respond is the:
a. ​gallbladder.
b. ​kidney.
c. ​liver.
d. ​stomach.
e. ​pancreas?

Answers

Pancreas is the answer

Answer: Option E. Pancreas

Explanation:

When the blood glucose level rises after a meal, the first organ to respond is the Pancreas.

When the blood sugar levels rise, insulin is released by pancreas.  Insulin released in the bloodstream helps to absorb the sugar and allows the liver to store sugar. Like this the process lowers the blood sugar level.

When blood sugar levels gets lower the pancreas are allowed to release glucagon, which allows the liver to release the stored sugar. If the blood sugar levels rise, the release of glucagon is stopped.

Hence, the correct option is Pancreas.

Where is an anglerfish likely to be found

Answers

The majority of anglerfish species can be found in the depths of the Atlantic and Antarctic Oceans. Hope this helped!
The anglerfish is normally found at the bottom of the sea.

Hope this helps!! ☺♥

You are attempting to isolate cells for your karyotype, and you find one cell in each of the phases (prophase, metaphase, anaphase, and telophase). which one is best suited for a karyotype?

Answers

Karotypes are best prepared using cells that have been arrested in metaphase. In metaphase or prometaphase, the chromosomes are most condensed.

There are 20 different amino acids. what makes an amino acid different from another

Answers

different side chains (R groups) attached to a carboxyl carbon

The 20 different amino acids gets differ from each other by varying side chain, i.e., R group.

What are amino acids?

Amino acids are compounds that form proteins when they integrate. The fundamental components of life are amino acids and proteins.

Amino acids are left over after proteins are metabolized or broken down. To help the body, the human body utilizes amino acids to start making proteins: Food is broken down.

Amino acids are organic compounds that possess amino and carboxylic acid functional groups, as well as an amino acid-specific side chain.

Amino acids differ in terms of their side chains, that are made reference to as R groups. Each amino acid's R group will have a distinct structure, electrical charge, and polarity.

Thus, this R group make the amino acids different.

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Which microscope is often used to view metal surfaces? scanning electron microscope scanning tunneling microscope transmission electron microscope compound light microscope

Answers

Answer:

The answer is B

Explanation:

Scanning tunneling microscope is often used to view metal surfaces. The correct option is B.

What is scanning tunneling microscope?

Scanning tunneling microscopy, is a visualization method that generates ultra-high quality pictures at the atomic scale without the utilization of light or electron beams. Gerd Binnig and Heinrich Rohrer, two IBM scientists, devised STM in 1981.

STMs are useful since they provide investigators with a three-dimensional profile of a surface.

This is usually allowing them to examine a wide range of characteristics such as roughness, surface defects, and determine things about atoms such as size and conformation.

Scanning tunneling microscopes are microscopes being used examine metal surfaces.

Thus, the correct option is B.

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1. What is matter? (Points : 1)
Matter is anything that is made of organic substances and is found on the earth.

Matter is anything that is made of atoms and that has mass.

Matter is an element.

Matter is a compound

Answers

Hello!

The correct answer to your question is the second option: Matter is anything that is made of atoms and that has mass.

I Really Hope This Helped You, Good Luck With Your Studies! :)

Answer:

Matter is anything that is made of atoms and that has mass.

Explanation:

Matter is anything that occupies space and has mass

Please help me fast , Thank you (:

Scientists find evidence that the genes involved in tooth development exist in chickens, even though chickens do not normally develop teeth. The formation of teeth in chickens can be controlled by introducing a virus into chicken embryos that "turned on" their tooth-developing gene. They find that the beaks of the virus-modified chicken embryos contain cone-shaped teeth similar to embryonic crocodile teeth. Which of the following best describes the conclusion that can be drawn from this experiment?

a As bird evolution continues, birds like chickens will develop teeth like dinosaurs and reptiles.
b The growth of teeth in chickens supports the hypothesis of a common ancestor between birds and reptiles.
c The chickens with teeth are more closely related to crocodiles than they are to regular toothless chickens.
d With enough genetic engineering, chicken embryos can develop into reptiles like crocodiles.

Answers

b The growth of teeth in chickens supports the hypothesis of a common ancestor between birds and reptiles. This is a generally accepted hypothesis, and i'd go with this answer. Obviously we can't say whether chickens will have teeth with certainty, the chickens with teeth are clearly still chickens, and a baby croc isn't hatching out of a chicken egg any time soon.

Smokers are more susceptible to respiratory infections because

Answers

The cilia (tiny hairs lining their lungs) in their lungs are moving gently to keep mucus and dirt out of your lungs, but since the smoke gets in their lungs it damages the cilia and cause mucus build up and dirt build-up causes the higher risk for respiratory infections.
Hey there,
For a more simplified explanation, their respiratory passages lose cilia, which would otherwise remove bacteria

Hope this helps :))

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A client is en route to the emergency department after sustaining a gunshot wound to the chest. Which priority nursing action should the nurse take to prepare for the arrival of the client?

Answers

In gunshot wound, the patient would be at risk of bleeding to death. The nurse should prepare fluid resuscitation using blood transfusion. The nurse could also be using crystalloid fluid before the blood is prepared. Preparing the operation room might be necessary depends on the patient condition but it won't be the initial treatment.

Which of the following organisms causes malaria?

Anopheles mosquitoes
Rats
Flies
Protozoan

Answers

The correct answer is option Protozoan.

Malaria is caused by the  Protozoan parasite called Plasmodium. It is transmitted by mosquito female Anopheles which bites between the dusk and dawn.

It is an acute febrile illness with an incubation period of 7 days or longer. its symptoms include chills, headache, weakness, abdominal pain, et cetera.

The initial symptoms is mild but later it can be severe.

The organism that causes malaria is a protozoan. The correct option is D.

The protozoan species Plasmodium is responsible for causing malaria in humans.

Malaria is a vector-borne disease transmitted to humans through the bites of infected female Anopheles mosquitoes.

These mosquitoes serve as the vector for the Plasmodium protozoan, which enters the human bloodstream during a mosquito bite and infects red blood cells, leading to the onset of malaria.

When an infected mosquito bites a human, it injects sporozoites, which are the infective form of the Plasmodium parasite, into the bloodstream.

From there, the sporozoites travel to the liver, where they multiply and develop into merozoites.

Therefore, the correct option is D.

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Complete question:

Which of the following organisms causes malaria?

A. Anopheles mosquitoes

B. Rats

C. Flies

D. Protozoan

For the DNA Base Sequence AAT, what is the matching mRNA Codon? Also, what is the correct tRNA Codon that binds to the mRNA Codon? And what is the correct amino acid that is coded by the base sequence?

Answers

UUA, which would be Leucine ( Leu)

A client, admitted to the hospital with a fractured hip, is scheduled for surgery for a total hip replacement. in which position should the nurse place the client's affected limb after surgery?

Answers

in a orthopneic position

Final answer:

Post-surgery for a total hip replacement, the affected limb should be positioned in neutral with a slight hip abduction to prevent dislocation and minimize the risk of complications such as DVT and pressure ulcers.

Explanation:

After a client undergoes surgery for a total hip replacement, it is critical to position the affected limb properly to prevent dislocation and facilitate healing. The limb should be kept in a neutral position, with the toes pointing upwards and the hip in slight abduction (away from the midline of the body) to prevent cross-legging and excessive bending. This careful positioning not only helps the hip prosthesis to stabilize but also minimizes the risk of complications such as deep vein thrombosis (DVT) and pressure ulcers.

If the fat in a container is solid at room temperature, what type of fat is it?
a. ​saturated fat
b. ​monounsaturated fat
c. ​trans fat
d. ​short-chain fatty acids
e. ​polyunsaturated fat

Answers

saturated fat.........

More cortical space is dedicated to areas of the body that are more sensitive. this best describes the

Answers

Organisation of the primary somatosensory cortex is the more cortical space is dedicated to body parts that are more sensitive. The left PSC receives and processes sensory information from the right side of the body and vice versa.

. A major concern about increasing global temperatures is that a large portion of polar ice could detach and melt into the ocean. If this happened, which two spheres would interact?
A. geosphere and atmosphere
B. cryosphere and biosphere
C. hydrosphere and atmosphere
D. cryosphere and hydrosphere

Answers

The answer is
B. cryosphere and biosphere

The correct answer is D. Cryosphere and hydrosphere.

Explanation

The Cryosphere refers to the parts of solid-state water on the earth's surface, including glaciers, ice sheets, frozen terrain, ice in lakes, rivers, and seas, among others. On the other hand, the hydrosphere refers to the layer of land composed of water mainly in a liquid state, including oceans, seas, rivers, lakes, lagoons, among others. According to the above, if a glacial falls off and falls into seawater to melt there, the layers of the earth that are interacting are the hydrosphere and the cryosphere. So the correct answer is D. Cryosphere and hydrosphere.

How are asthma hyperventilation and anaphylactic shock alike?

Answers

In both you are unable to breathe.

To locate a specimen on a prepared slide with a compound microscope, a student should begin with the low-power objective rather than the high-power objective because the

Answers

Answer: The field of vision is larger under low power objective than under high power.

Explanation: it will damage the slide if its on high power

e spend our lives in visible light without risks to our health. Yet exposure to UV waves in sunlight can cause skin cancer. What is the BEST explanation for this?

Answers

Well UV lights has a wavelength which is shorter than visible light which I think is why it is harmful.

What distribution of phenotypes follows a normal bell shaped curve?

Answers

The distribution of phenotypes that follows a normal bell curve would be a normal distribution

Acetylcholinesterase breaks down acetylcholine to prevent additional __________.

Answers

The acetylcholinesterase breaks down into acetylcholine in order to prevent additional firing of neurons in which may be found in the neuromuscular junction. The acetylcholinesterase is considered to be an enzyme that is usually found in the autonomic nerve, the endings of voluntary nerves and the parasympathetic involuntary nerves.

1. When potatoes are in the ground, do they swell with water when it rains? If not, how do you explain that. If so, what are the advantages or disadvantages in this adaptation?

Answers

Salutations! The answer you are looking for is: The actual potato only holds energy. The roots soak up the water and transfer the necessary nutrients to the food, rather than the potato gathering it directly. The potato may swell a little bit, however for the most part it isn't able to suction enough, nor does it need to. 

hope this helps

Atom A has an atomic number of 19 and mass number of 40. Atom B has an atomic number of 20 and a mass number of 40. Which of these is an accurate statement?

A) Atom A has more protons than Atom B.
B) Atom A has one less proton and one more neutron than Atom B.
C) Atom A has an extra nucleon compared to Atom B.
D) Atom A has one more proton and one more electron than Atom B.

Answers

The Correct answer is not shown. The correct answer would have to say Atom A has one proton than Atom B because in the question it says Atom A has an atomic number of 19 and Atom B has an atomic number of 20.

Atom A has one less proton and one more neutron than Atom B, as the mass number is the same but the atomic number differs by one. Hence, option B is correct.

The correct statement about Atom A with an atomic number of 19 and mass number of 40, and Atom B with an atomic number of 20 and a mass number of 40, is that Atom A has one less proton and one more neutron than Atom B. This is because the atomic number indicates the number of protons and the mass number is the sum of protons and neutrons. Since Atom A and Atom B have the same mass number but different atomic numbers, it can be deduced that Atom A must have one less proton and consequently one more neutron than Atom B in order to maintain the same mass number of 40.

The ________ is not the name of a pleistocene glacial episode in north america.

Answers

Hello!

The correct answer for the blank is: Dakotan.

I hope this helped you out! :)

Some rats have become resistant to common pesticides. Which statement best explains how the rats became able to resist those pesticides

Answers

We have been using pesticides for a very time now a rat likes to be alive living out in the streets like a thug so the body sends message to body help fight the pesticides. So now white blood cells are fighting battle against them. They begin evolving and become immune to the pesticides. 

In rivers and streams what causes sediment

Answers

"Sediment can come from soil erosion or from the decomposition of plants and animals. Wind, water and ice help carry these particles to rivers, lakes and streams"

Here's a link for more info: https://cfpub.epa.gov/npstbx/files/ksmo_sediment.pdf

Hope this helps! 

PLEASE HELP! WILL MARK AS BRAINLIEST!!!

Which description is not a property of an acid?
A. Sour taste
B. Corrosive
C. Slimy feel
D. Dissolves metals

Answers

C. Slimy feel, you can know this because citric acid or Lemmon juice is not slimy.

A description that does not reveals a property of acid is a Slimy feel. Thus, the correct option for this question is C.

What are the properties of an acid?

The properties of acid are as follows:

Acids have a sour taste. Acid changes the color of blue litmus red. Acids significantly react with active metals to yield hydrogen gas.They are good conductors of electricity.Thye reacts with carbonates in order to produce carbon dioxide gas.

Among the options, give, sour taste, corrosive in nature, and dissolves metals in order to yield hydrogen gas are the properties of acids. But a slimy feel is a characteristic feature of strong bases such as NaOH. They are slippery and slimy in nature. Hence, a slimy feel is not a property of acid.

Therefore, the correct option for this question is C.

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What event directly triggers the release of neurotransmitter shown in a?

Answers

The event that directly triggers the release of the neurotransmitter is THE DIFFUSION OF CALCIUM IONS INTO THE AXONAL TERMINUS.
Neurotransmitters are chemical messengers which relay information throughout the entire body system. There are many neurotransmitters and different events are responsible for triggering them up.
Final answer:

An action potential at the presynaptic neuron's axon terminal triggers the opening of voltage-gated calcium channels. This leads to the release of neurotransmitters through exocytosis. The neurotransmitters then bind to the postsynaptic receptors, possibly triggering a new action potential.

Explanation:

The event that directly triggers the release of neurotransmitters, such as acetylcholine (ACh), is the arrival of an action potential at the axon terminal of the presynaptic neuron. This action potential causes voltage-gated calcium channels to open, leading to an influx of Ca²⁺ ions. These calcium ions facilitate the fusion of synaptic vesicles containing neurotransmitters with the presynaptic membrane, ultimately causing the release of neurotransmitters through exocytosis into the synaptic cleft.

Once in the synaptic cleft, the neurotransmitter, like ACh, binds to receptors on the postsynaptic membrane. This binding opens ion channels, such as ligand-gated Na⁺ channels in the case of ACh at the neuromuscular junction, which leads to depolarization of the postsynaptic neuron and a possible generation of a subsequent action potential.

Neurotransmitter release is triggered by the opening of voltage-gated calcium channels in the presynaptic neuron. When an action potential reaches the axon terminal, these channels open, allowing calcium ions to enter the presynaptic cell. The increase in calcium concentration inside the cell triggers the fusion of neurotransmitter vesicles with the presynaptic membrane, leading to the release of neurotransmitters into the synaptic cleft.

What are two structures that are found in plant cells that are not found in animal cells

Answers

Two I can think of are chloroplasts and cell walls.
Two structures that are found in plant cells that are not found in animal cells are the cell wall and the chloroplasts
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Simplify: Negative two and one-third minus negative ten and one-sixth a Negative twelve and one-half b Twelve and one-half c Seven and five-sixths d Negative seven and five-sixths Determine the answer to (3) + (5) and explain the steps using a number line. please give example and how you did itUse absolute value to express the distance between 12 and 15 on the number line.a |12 (15)| = 27b |12 (15)| = 3 c |12 (15)| = 3d |12 (15)| = 27please help im failing and its stressing which numbers below are even? 6, 12, 15, 24, 30 Which of the following rates measures how many children are being born in a country (in relation to the size of its population)? A. birth rate B. migration rate C. urbanization rate D. death rate Evaluate 8 + W/4 when W = 16. Paraphrase what the pardoner says? What is his exclusive purpose (No Answer Choices) (Written answer) Please help me fast , Thank you (:Scientists find evidence that the genes involved in tooth development exist in chickens, even though chickens do not normally develop teeth. The formation of teeth in chickens can be controlled by introducing a virus into chicken embryos that "turned on" their tooth-developing gene. They find that the beaks of the virus-modified chicken embryos contain cone-shaped teeth similar to embryonic crocodile teeth. Which of the following best describes the conclusion that can be drawn from this experiment?a As bird evolution continues, birds like chickens will develop teeth like dinosaurs and reptiles.b The growth of teeth in chickens supports the hypothesis of a common ancestor between birds and reptiles.c The chickens with teeth are more closely related to crocodiles than they are to regular toothless chickens. d With enough genetic engineering, chicken embryos can develop into reptiles like crocodiles. How does this map reflect Snow's findings as well as enhance the reader's understanding of the text? What relationship do you see between the location of the pump and the black dots? Note that the rectangles of black dots represent deaths that Snow recorded in the cholera outbreak and a black circle marks the location of the Broad Street pump Steam Workshop Downloader